EON emphasizes the guideline task model, temporal queries, use of domain ontologies, and explanation.

In PROforma safety is the center of focus.

Asbru focuses on expressing guideline intentions. It is developed as part of the Asgaard project.

PRODIGY aims at facilitating knowledge engineering by domain experts by producing a simple, understandable model sufficiently expressive to represent chronic disease management guidelines.

PATMAN and other work done by the Medical Informatics group at the University of Pavia emphasizes workflow integration into healthcare organizations.

Prestige uses a declarative approach to representing knowledge about the healthcare enterprise, the patient health record, and the protocol. PRESTIGE has distinct representations for protocols and acts, since consulting a guideline and following its recommendations are different activities.

GEM is a method that enables markup of the heterogeneous information contained in narrative clinical guidelines. Major concepts relate to a guideline's identity, developer, purpose, intended audience, method of development, testing review plan and knowledge components.

Alchemist is a method for automatically creating guidelines from decision models
 

OpenClinical is an association of individuals, organisations and companies collaborating on the development and dissemination of knowledge management technologies for patient care.

USAM provides abstractions (data model) of clinically-relevant services and actions. It is developed under HL-7, and models the clinical part of HL-7's Reference Information Model (RIM).